Recent work from our lab is published as part of the ACS Chemical Biology Young Investigator Special Edition!
We discovered that the YAP-TEAD1 signaling axis is disrupted when human stem cell-derived podocytes experience biomechanical injury. These results highlight CTGF and Cyr61 as potential therapeutic targets/biomarkers for patient stratification, which could also help improve the understanding of human kidney disease mechanisms.
Congratulations to graduate student and first-author Morgan Burt and all the co-authors for their contributions!
Full paper: Adriamycin-Induced Podocyte Injury Disrupts the YAP-TEAD1 Axis and Downregulates Cyr61 and CTGF Expression | ACS Chemical Biology