A new research publication from our team leveraged human stem cell-derived models to uncover the complex molecular and cellular mechanisms underlying diabetic nephropathy

We are excited to share our new research studies published in Matrix Biology Plus, where we leveraged human stem cell-derived models to uncover complex molecular and cellular mechanisms underlying diabetic nephropathy. By creating a model of hyperglycemia-induced podocytopathy, we gained new insights into specific molecular signaling pathways that drive podocyte injury and matrix remodeling in diabetic kidney disease. We found that targeting changes at the podocyte-ECM interface may offer promising strategies to halt or mitigate disease progression. We are excited about the possibility of these findings to guide strategy for better patient outcomes.
Congratulations to Musah Lab's graduate student Yasmin Roye for leading this study and to all co-authors for their contributions.

Link to the full open access paper: A human stem cell-derived model reveals pathologic extracellular matrix remodeling in diabetic podocyte injury - ScienceDirect